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Relumins Oral Glutathione Spray Vials Formula 6000mg Plus Zinc Standard Dose: 3 Pumps 4 times a day for 12 total pumps per day Max Dose: 6 pumps 4 times a day for 24 total pumps per day Hold Liquid in mouth and keep for 3-5 minutes then swallow The package of 2 vials should last two weeks at standard dose Treatment results are evaluated every 3 months Transition to maintenance once desired skin tone is reached Additional Instructions to Apply the Spray Pump to Bottle: When applying spray pump to bottle, take extra time to affix pump securely on the bottle with no gaps between spray collar and bottle

6.2 Inhibition of the JAK-STAT pathway Baricitinib, an oral small-molecule inhibitor of the JAK family of protein tyrosine kinases, has shown clear clinical efficacy in treating chronic inflammatory diseases, such as rheumatoid arthritis, via selective inhibition of JAK1 and JAK2 (289, 290)

3,4 It is known to be antimelanogenic, thereby associated with melanin production

Plots of log [(F 0 F)/F] versus log [PEI-f-Ag-NP] are shown in Figure 8A