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519 Specifically, high blood glucose-induced insulin resistance in CRC cells leads to increased BMP4 expression, which activates the BMP4-Smad1/5/8 signaling pathway

Associated variants are on ATP8B1 (responsible for PFIC1 and (B)RIC1) and ABCB11 (determining PFIC2 and (B)RIC2) genes [9], but cases linked to MYO5B variants have also been recently described [60]