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4a, b, c and 9c, d, the mean fluorescence intensity was calculated for entire images

Research suggests that inhibiting PARP1 can enhance the functionality of senescent cells by increasing NAD + levels and SIRT1 activity 159

AMPylation is a reversible modification, signaling by this mechanism can be modulated by specific stimuli 36,37,38

The skn-1::GFP results were consistent with the RTqPCR results shown in Supplementary Figure S3b where mRNA of skn-1 was not significantly changed with the glucose-fed bacterial diet