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Additionally, autophagy helps the removal of damaged mitochondria, suppresses NLRP3 inflammasome activation and subsequent inflammatory cytokine production by reducing ROS release, and promotes the survival of RPE and photoreceptor cells, thereby mitigating inflammatory damage (142144)

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Without it, our antioxidants will become used up and oxidative damage (the leading culprit for skin aging) builds up

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GA decreases the activity of catalase (CAT), ascorbate peroxidase (APX), and superoxide dismutase (SOD), leading to reduced scavenging ability for ROS, consequently resulting in peroxidative damage of membranes followed by release of hydrolytic enzymes (Jones and Smirnoff, 2005

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In this regard, it will be important to evaluate whether persistent immune activation after COVID-19 recovery relies on the presence of undetectable SARS-CoV-2 virus, viral RNA and/or viral antigens and also assess the contribution of unrepairable cellular and tissue damage

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doi: 10.3390/separations11090257 9

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