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doi: 10.1038/s41580-019-0101-y 111 HolleyA

Cancer-cell-secreted Exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

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While current research has shown some efficacy of SHMT inhibitors in cancer treatment, the fact that SHMT inhibitors target a central metabolic enzyme present in both normal and tumor cells means that potential toxicity remains one of the greatest challenges on the path to clinical translation