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Blood was collected from left/right jugular veins of the rats using sterile catheters

In another study performed to check the effectiveness of selenium (Se) and CBZ treatment using adult rats with pentylenetetrazol (PTZ) induced seizures, it was observed that simultaneous treatment with Se and CBZ alleviated PTZ-induced effects by diminishing epileptic spikes and markers of oxidative stress except lipid peroxidation, which was increased 18

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(2021) 28:27384.e6

Kinetic studies also confirmed that SIRT4 was the first mammalian sirtuin discovered to be physiologically regulated by the [NAD + ]/[NADH] instead of by [NAD + ] (Pannek et al., 2017) as 30 M NADH, a physiological concentration found in the mitochondrial matrix (Sallin et al., 2018), inhibited SIRT4 activity