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Alternatively, the suppression of the lipid flippase solute carrier family 47 member 1 (SLC47A1) enhances ferroptosis by favoring the ACSL4sterol O-acyltransferase 1 (SOAT1) pathway over the ACSL4LPCAT3 pathway, leading to the production of PUFA cholesterol esters in pancreatic cancer cells [102]

Representative study selection From the extensive pool of studies, those that provided clear, reproducible, and significant outcomes were selected as representative examples

The maximal L-lactate in pyruvate dehydrogenase deficiency is nearly identical to the maximal D-lactate in LDHD deficiency, and including the pyruvate to represent the totality of what is blocked by the mutation in the enzyme does not meaningfully change the comparison

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Not only did patients lose weight as expected -- an average of 4.4 kg from baseline -- but triglyceride and low-density lipoprotein (LDL) cholesterol levels also declined significantly