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Fourteen patients (48.3%) had diabetes

Nitric oxide and cyclic nucleotide signal transduction modulates synaptic vesicle turnover in human model neurons

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While nuclear factor erythroid 2-related factor 2 (NRF2) and CCAAT/Enhancer Binding Protein (CEBP) also contribute to a minor increase in CHAC1 transcription, their roles are less pronounced compared to ATF4 ( FIGURE 4 ATF4 and ATF3 regulate CHAC1 expression by binding to specific sites within its promoter, the ATF/cAMP response element (CRE) at position 267 and the ATF/CRE modifier (ACM) motif at 248

Data were sourced from the GBD database ( The GBD data used in our analysis were downloaded on April 3, 2024