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Mechanistically, these effects appeared to be mediated through mitochondrial uncoupling, AMPK activation, modulation of mTOR and PPAR signaling, improved mitochondrial bioenergetics, antioxidant defense and global metabolic reprogramming (Fig

105 DNA repair HK2 exhibits moonlighting functions in the nucleus, with its overexpression increasing chromatin accessibility at DNA repair sites, thereby reducing DNA double-strand breaks