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Journal of Biomedical Nanotechnology 13: 313-323

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Including the PI3K/AKT/PTEN and insulin/IGF-1 signaling pathways mentioned earlier [76, 77], as well as epigenetic changes such as the TME and methylation, which may cause abnormal activation of mTOR [78, 79]

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In these cases, telestroke neurologists take decisions about transferring based on simple imaging

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