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FUNDING This work was supported by the by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2023R1A2C2003479), the Bio&Medical Technology Development Program of the NRF funded by the MSIT (NRF-2019M3E5D3073102), and the Basic Science Research Program funded by the Ministry of Education (NRF-2020R1I1A1A01071665 and RS-2023-00248873)

Efficacy of erdosteine 900 versus 600 mg/day in reducing oxidative stress in patients with COPD exacerbations: results of a double blind, placebo-controlled trial

While cystine deprivation in the TME has been reported to inhibit tumor growth by inducing tumor cell ferroptosis [45], our findings suggested that cystine starvation severely impairs T cell anti-tumor immunity

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Highly acidic ingredients (like L-Ascorbic Acid or Glycolic Acid) can "chelate" the copper, essentially breaking the bond and making the peptide ineffective