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When determining the Alanine to Lysine ratio as an indirect measure of mitochondrial distress we found that unaffected children had an average ratio of 5.8 and those with konzo have an average ratio of 6.9, both of which are substantially higher than the expected ratio of less than 3 for healthy adolescents (Fig

Human Cu,Zn-SOD has a high degree of sequence homology (83%) with the bovine Cu,Zn-SOD, along with similarities in three-dimensional structure, domain organization, amino acid sequence, protein folding, and catalytic properties [41,42]

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PG and VK were responsible for writing the manuscript

P.KurinijN.et al (2013)