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Sci Rep (2021) 11(1):6849

Biomimetic chiral nanotopography for manipulating immunological response

GaraycoecheaJICrossanGPLangevinFMulderrigLLouzadaSYangFet al

Interestingly, in the SN of healthy individuals, the concentration of oxidized proteins was found to be twice that of the caudate, putamen, and the frontal cortex, indicating that susceptibility of SN to oxidative stress may contribute to the selective neuronal degeneration [24]

Additionally, an open-label, single arm pilot trial (OPTIMA) was designed to assess the efficacy and safety of inhaled GM-CSF (Molgramostim nebulized solution) in treating NTM-PD in adults with non-CF bronchiectasis ( Although these data have not fully demonstrated the exact efficacy of NE inhibitors in the treatment of bronchiectasis, researchers continue to explore and optimize the therapeutic strategies for NE inhibitors, including the development of inhaled NE inhibitors to increase the concentration of the drug in the lungs and thus improve the clinical efficacy