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Owing to the abovementioned reasons, it is difficult to find highly selective DUB inhibitors, which explains why most DUB inhibitors are multitargeted and are likely to cause intolerable side effects 162

Antimalarial drugs such as pamaquin are oxidizing compounds that deplete reduced glutathione

Survival assay Measurement of life span in wild type and park 13 flies was essentially performed as per established protocols 58

Bovine type-II collagen solution (2 mg/mL) and complete Freunds adjuvant (CFA) (4 mg/mL) were shaken to emulsion

The levels of serum ferritin can reflect the bodys iron reserves and are currently the most sensitive indicator for detecting iron deficiency or iron overload