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To focus on oxidative stress as a main damaging factor in an in vitro model is reasonable, as the diverse upstream causes for PN (hyperglycemia, dyslipidemia, some chemotherapeutics, alcohol abuse) converge into one prominent metabolic disturbance: the production of ROS and, thus, increased oxidative stress

Lysozyme encapsulated gold nanoclusters: Effects of cluster synthesis on natural protein characteristics

Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer

Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains

The limited human data includes a pilot study of IV infusion in 2 healthy adults (showing no adverse effects) 3 and an intra-articular injection study where 11 of 12 patients (91.6%) reported significant improvement in knee pain 4