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For the tested inhibitors, we used doses in the known IC50 ranges, evidencing minimal effects on cell viability

Takano A, Arakawa R, Ito H, Tateno A, Takahashi H, Matsumoto R et al (2010)

Soft Matter 10, 26002611

Enriched in di- and tripeptides, PH facilitates protein synthesis of the skeletal muscle via anabolism, leading to an increase in skeletal muscle mass [186, 187]

In addition, SIRT1 deacetylates FOXOs and stimulates FOXO-dependent antioxidant [such as catalase (CAT), manganese superoxide dismutase (MnSOD) and thioredoxin] expression to eliminate ROS in endothelial cells, and prevent endothelial dysfunction [78-80]