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This pattern is not unique to tirzepatide but reflects the biology of obesity and metabolic adaptation

Furthermore, genes that are exclusively expressed in biological males, such as the testes exclusive genes GPR64 and SPINT3 , accumulate deleterious mutations [111]

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases (2)

the focus will be different, so these effects might not be as potent (or immediate), but they still may occur

References 1 AgarwalP