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None of these studies reported serious adverse events

PostExamination Care Patients receiving isotretinoin undergo structured followup for diseasecontrol, medicationadherence, and adverseevent monitoring, including education about earlysign recognition of systemic complications such as abdominal pain, jaundice, or moodchanges

Carr MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G (2003) Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals

23 Daniel Bovet synthesized antihistamines in 1937 and earned the Nobel Prize in Physiology or Medicine in 1957, which brought hope in the treatment of allergic diseases and has been in clinical use to this day

Heat shock factor 1 attenuates 4-hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL