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High affinity binding sites are located at two sites on the -chain, specifically at the N-terminal domain and the first Kringle domain

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Although the mechanism of action is virtually unknown at this time, preliminary clinical data suggest that vitamin D supplementation in Crohn's disease patients in remission may have a prominent role in intestinal permeability maintenance over time (362)

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Serum vitamin B12 was assessed in 60 symptomatic cases of oral lichen planus and 60 healthy age and gender matched controls