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[60] reported decreases in MT mRNA levels in response to high glucose concentration in -cells in a mice model

Activated Nrf2 translocates to the nucleus, where it triggers the expression of antioxidants such as glutathione redox system components, enzymes that regulate iron metabolism, and other pertinent molecules, which can inhibit ferroptosis

Blum MA, Hayashi Y, Xiao L, Suzuki A, Sabloff B, Maru DM, Taketa T, Welsh J, Lin SH, Lee JH, Bhutani MS, Weston B, Hofstetter WL, Swisher S , Ajani JA

These approaches also reduce systemic side effects and offer more personalized treatment options, particularly in patients with variable complement activation due to pre-existing liver disease, steatosis, or autoimmune backgrounds (144)

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