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Moreover, inhibition of GS activity in TAMs induces the polarization of M2-type TAMs toward the M1 type, accompanied by a decrease in glutamine levels and increase of succinic acid and accumulation of HIF-1

Choi S, Lovinger DM (1997)

Immune cell-derived bionic functional materials are effective carriers for targeted delivery of drugs to tumors owing to the secondary phenomenon of inflammatory chemotaxis [115]