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(2) Alternative Pathway for Certain Antimicrobial Products For applications received for new technology add-on payments for certain antimicrobial products, beginning with FY 2021, if a technology is designated by FDA as a QIDP and received FDA marketing authorization, and, beginning with FY 2022, if a drug is approved under FDA's LPAD pathway and used for the indication approved under the LPAD pathway, it will be considered not substantially similar to an existing technology for purposes of new technology add-on payments and will not need to meet the requirement that it represent an advance that substantially improves, relative to technologies previously available, the diagnosis or treatment of Medicare beneficiaries

[link] Xu, J., Shao, Z., Glass, K., Bauer, D.E., Pinello, L., Van Handel, B., Hou,S., Stamatoyannopoulos, J.A., Mikkola, H.K.A., Yuan, G.-C

Esophageal dysfunction is the most frequent visceral change, including difficulty in swallowing (dysphagia) and acid return flow (reflux) Decreased mobility of the small intestine may also be associated with malabsorption resulting from anaerobic bacterial overgrowth

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Yoder JM, Brandeland M, Engeland WC