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Notably, the activation of mTOR or S6K1 can lead to the phosphorylation of the insulin receptor substrate-1 (IRS-1) (4345), thereby inhibiting insulin signaling pathways (46)

The direct binding of TRAF6 to LMP1 is required for CTAR2 signalling CTAR2 signalling is defective in TRAF6-deficient mouse embryonic fibroblasts (MEFs) and can be rescued by exogenous TRAF6 expression 20,28,29,31