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Serotonergic modulation is more modest, and the compound does not produce the anxiolytic-sedative spectrum characteristic of serotonergic anxiolytics or benzodiazepines

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Indeed, a recommendation made in the recent oil spill dispersant report (NASEM, 2020) was that toxicity tests should not be developed to represent or replicate field-exposure conditions (which they cannot do), but rather for use to further develop and refine models so that integrated fate, exposure and effects models can support the decision-making process during an oil spill response (i.e., by comparing all of the options

As the disc degenerates and becomes more dehydrated, the lamellar structure of the annulus fibrosus becomes disorganized and the disc loses its structural integrity 9