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In an in vitro model of diabetes retinopathy, AC, reduced retinal pigment epithelial cell damage through inhibiting Keap1 expression, endorsing nuclear translocation of Nrf2, elevating NQO1 and HO-1 expression, reducing ROS, and increasing superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and glutathione peroxidase (GSH-Px) (Yang et al