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Indeed, a recent study showing long-term dietary serine and glycine starvation leads to retinal defects in mice 47 suggests that shorter term application of these approaches for cancer therapy are likely to be required

Development of an effective systemic therapy for uHCC patients with CP-B is needed in the near future

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One aspect of the invention pertains to the administration of one or more NNMT inhibitors by, for example, contacting one or more cells of an animal to: muscular disorders including, but not limited to, sarcopenia, muscle atrophy, Duchenne muscular dystrophy, Becker muscular dystrophy, Limb-girdle muscular dystrophies, Pompe disease, cardiac myopathies, pulmonary disorders