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Biologically important metal coordination complexes: (Left) Heme, the "business end" of hemoglobin

J Comp Neurol 373:157172 Lubos E, Loscalzo J, Handy DE (2011) Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

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By positioning two substrates within the enzymes active site, their collision frequency increases, thereby accelerating the chemical reaction ( 25 )

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