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The nanocomposite architecture ensures sustained drug release, prolonged half-life, and enhanced tissue penetration, collectively mitigating gouty inflammation and preventing urate crystal-induced nephropathy ( Additionally, PEGdrug conjugates are prevalent functionalized carriers where PEG modifies therapeutic agents (e.g., uricase) to improve pharmacokinetics and reduce immunogenicity (Ozer et al., 2022)

These molecules can be receptors/transporters substrates, substrate derivatives, substrate-binding moiety fragment molecules, antibodies or antibody-binding fragments against the receptors/transporters

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For instance, genes involved in synaptic plasticity regulation, such as SH2D5 and NPTX2, may contribute to migraine chronicity (Winsvold et al., 2018)

Besides SAM, other metabolites derived from the methionine cycle also contribute to the regulation of T cell responses, as reviewed previously ( Section 1: importance of ROS, GCN2, and methionine pathways in regulating T cell anti-tumor immunity Importance of ROS in T cells Reactive oxygen species (ROS) play an essential role in T cell activation, subset formation, and effector function