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in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )

In this study, significant positive correlations were observed between tryptophan, tyrosine, and xanthine abundances in the EWAT and the relative abundance of Parasutterella in the cecal microbiome (Supplementary Table S5, outliers removed)