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bioRxiv2024 November 22

Chakravarti, X

Moreover, quantitative analysis of sensing signals using MDMOC was conducted based on standardized calibration curves established under in vitro conditions, with signals from standard solutions serving as controls

To move Epitalon from experimental to evidence-based, several developments are essential: Randomized, double-blind, placebo-controlled clinical trials, ideally targeting specific endpoints (sleep, immune aging, telomere attrition) Toxicology and long-term safety studies, including exploration of stereoisomer effects and off-target consequences Validated delivery systems (e.g., dendrimer-conjugates, transdermal patches) that make real-world use feasible Pharmacodynamic biomarkers, to identify responders and track efficacy objectively over time Epitalon is not snake oil, but its also not a magic bullet

10.1007/s00289-023-04688-7 206 MaitiD.TongX.MouX.YangK