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NK cells can exert cytotoxic effects without antigen pre-sensitization, but some metabolic features in the TME hinder NK cell immunotherapy [228]

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Adaptive processes of melanoma cells allow them to offset the effects of medicines, resulting in a multidrug-resistant phenotype [70]

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doi: 10.1016/j.phymed.2022.154308 119 ZhaoHZhangNLiZDongWLiuS

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