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Chang, T

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While following the instructions the calibrator should be handled and measured in the same manner as a patient specimen.

In particular, the constant high urinary background levels of NAcLys-BDA in the range of NAcLys-[ 13 C 4 ]-BDA concentrations observed in response to the highest dose of [ 13 C 4 ]-furan (1 mg/kg bw) and estimated to correspond to a furan intake of 1.6 and 2.1 mg/kg bw in male and female rats, respectively, provide clear evidence for a significant but yet unexplored source of furan or its metabolites

The mTORC1-S6K1 axis also promotes phosphorylation of SRPK2 (SRSF protein kinase 2), and, in concert with its phosphorylation by CK1 (casein kinase 1), induces SRPK2 nuclear translocation and the splicing of lipogenic-related transcripts (Lee et al., 2017)