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While high-dose MTX is commonly used in cancer treatment, low doses have been shown to be beneficial for the treatment of autoimmune disorders

Antisense oligonucleotides (ASOs) are the synthetic nucleic acid molecules that can complementarily pair with a target mRNA to activate the endogenous RNase H enzyme, leading to the degradation of mRNA, or to block the interaction of mRNA with RNA-binding proteins, which regulates the shearing or processing of mRNA without degrading mRNA (36)