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Ghrelin agonist ipamorelin effects on the HPT axis

Individual response varies based on factors including metabolic rate, insulin sensitivity, activity level, and previous peptide experience

doi: 10.1038/nature13198 12 RoesslerMRollingerWPalmeSHagmannMLBerndtPEngelAMet al

Some researchers prefer nighttime-only application, reasoning that growth hormone release during sleep may synergize with the peptide signaling