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the antibodies of the invention stimulate EphA2 phosphorylation in the mouse cell lines including but not limited to CT26 and 4T1 at least about 10%, at least about 20%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, or at least about 90%, at least about 100%, at least about 110%, at least about 130%, at least about 140%, at least about 150%, at least about 160%, or at least about 170% more than control antibodies as described herein

Full-length T4 (43 amino acids, ~4,963 Da) contains the sequence Ac-SDKPDM A EIEKFDKSKLKKTETQ, placing methionine between residues 5 and 7

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Consistently, injection of lactate into mice results in elevated serum TGF-2 levels, and incubation of adipocytes with lactate causes increased TGF-2 concentrations in the media (Takahashi et al., 2019), though the underlying mechanism remains to be determined

Howlett 2014