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Clinical experience has shown that anti-CD38 antibody therapy is transforming treatment of MM owing to its anti-myeloma efficacy and manageable safety profile

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Discovery, Synthesis, and Biological Evaluation of Thiazoloquin[az]olin[on]es as Potent CD38 Inhibitors

6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

The studies summarized below are predominantly preclinical and should be interpreted accordingly