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Additional clinically significant irAEs included pneumonitis, colitis, hypophysitis, hyperthyroidism, hypothyroidism, nephritis, and hepatitis

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Our approach to identify pathways directly affected by Gsta4 over-expression and sequent reduction of mitochondrial 4-HNE load consisted in overlapping two independent databases of 4-HNE modified proteins, together with assessing their transcription in the OL lineage