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We investigated whether complex formation restores these effector functions of the AMG 966 Fc domain by significantly increasing avidity, which was plausible based on studies of how protein aggregation impacts FcR binding (1820) and published data exploring FcR binding properties of other TNF inhibitors (21)

DPI has also been employed in numerous studies as a ROS inhibitor due to its demonstrated efficacy in reducing superoxide production during reverse electron transport (20, 21)

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Tucker M, Liao GY, Park JY, et al

Over multiple vials, this adds up