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TRAF3 modulation: novel mechanism for the anti-inflammatory effects of the vitamin D receptor agonist paricalcitol in renal disease

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Concurrently, pathological signals originating from peripheral systems such as the gutbrain axis and spleenbrain axis continuously propagate to the central nervous system, persistently exacerbating the pathological processes within the central network and ultimately leading to the progressive loss of nigral dopaminergic neurons [3]