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Our tCho result is consistent with a prior pediatric study that also found lower prefrontal tCho in sport-related concussion in comparison to controls at 3 months, despite no group differences at the acute (2472 h) timepoint 16

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Further studies of natural products as immunomodulators in AL could help discover promising compounds against immune checkpoints

Manual rebuilding was performed on these models using the tools in Coot 46 , followed by iterative positional and B-factor refinement in real-space using phenix.real_space_refine 49 within Phenix 48

98,99,100 Under oxidative stress conditions, ROS may also interfere with mtDNA replication and repair mechanism