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To determine the efficacy of GshF-mediated GSH synthesis, we quantified GSH abundance from HEK 293T cells expressing either GshF or mito-GshF in the presence or absence of the mammalian GSH synthesis inhibitor buthionine sulfoximine (BSO) (Fig

Protein Cell 12(9):675679 Liu J, Kang R, Tang D (2022) Signaling pathways and defense mechanisms of ferroptosis

A 'substrate-limitation' model in FM is supported by elevated homocysteine levels observed in FM/chronic fatigue syndrome cohorts, by associations between symptoms and the MTHFR C677T (rs1801133) variant, and by gene-environment interactions showing that rs1801133 modifies the effect of physical activity on fatigue

Also, some cohort studies lacked detailed exposure intensity and duration data or were unable to evaluate cumulative effects over extended periods 273

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