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First, in vitro studies predominantly use immortalized cell lines (e.g., HepG2, L02) or primary hepatocytes under simplified lipid overload conditions, failing to recapitulate the complex in vivo microenvironment of NAFLDincluding crosstalk between hepatocytes, hepatic stellate cells, and immune cells, or systemic metabolic dysregulation

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Mol Biol Cell 16:2424-2432 Dejean LM, Martinez-Caballero S, Kinnally KW (2006a) Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis

12 ArnoldussenI.WiesmannM.PelgrimC.WielemakerE.Van DuyvenvoordeW.Amaral-SantosP.et al (2017)

Ma J, Du G, Li X, Zhang C, Guo J (2015) A major locus controlling malondialdehyde content under water stress is associated with Fusarium crown rot resistance in wheat