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This work was also funded by the Guangdong Provincial Bureau of Traditional Chinese Medicine (No.20241285) and Guangdong Basic and Applied Basic Research Foundation (No.2022A1515110790 and 2024A1515012478)

Mitochondrial antioxidant proteins in the first line of defense against ROS/RNS fall into three categories, including non-enzymatic antioxidants (i.e., GSH), direct enzymatic antioxidants (i.e., SOD2 and GPx), and indirect enzymatic antioxidants [i.e., glutathione reductases (GR), peroxiredoxins, and thioredoxins (Trx)] [96, 97]

10.1021/jm400393u J

For instance, administering statins alongside OATP1B1 inhibitors like gemfibrozil (a lipid-lowering agent) or cyclosporine A (an immunosuppressant) can elevate statin serum levels, thereby increasing the risk of statin-induced myopathy [27]

In addition, multifloral BP showed a higher concentration of mycotoxin than monofloral BP, whereas bee bread exhibited maximum amount of mycotoxins in analyzed samples (202)