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The binding of AGEs to their receptor (RAGE) activates the AGEs/RAGE signaling pathway, inducing inflammation, oxidative stress, cell apoptosis, insulin resistance, and damage to pancreatic cells 92

PMID: 42103759 Nat Commun INSIG1/2 succination mediated by the moonlighting function of ADSL promotes lipogenesis and liver tumorigenesis

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Ongoing research seeks to reduce side effects and create more targeted treatment strategies

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