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Indeed, combination of exome, transcriptome, and metabolome analyses of multiple NSCLC cell lines also clearly demonstrated that remarkable enhancement of glutamate excretion, cystine uptake, and glutathione synthesis is a striking and reproducible feature of NRF2-addicted cancer cells (Saigusa et al

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Further investigation in this exciting field is expected to provide detailed information for better understanding the function of H 2 S in different types of eye diseases, and to design more effective and safe approaches for H 2 S application in clinical settings