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Circulation 123 , 198695 (2011)

In addition to its effects on dopamine, nicotine enhances neuronal function by regulating the release of other neurotransmitters, such as glutamate and gamma-aminobutyric acid (GABA) (Lai et al., 2023

In this model, PINK1 or Parkin deficiency disrupts mitophagy, resulting in excessive mROS production, mitochondrial damage, increased TGF-1 expression and Drp1 recruitment in RTECs, all of which promote renal fibrosis