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exogenous IGF-1) have complementary but distinct effects

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Activated type I NKT cells release perforin/granzyme to induce tumor cell apoptosis, express FasL to initiate apoptosis via binding to tumor cell Fas, and secrete cytokines (IFN-, IL-4, tumor necrotic factor-) to enhance NK/CD8 + T cell cytotoxicity (106)

PMID: 31042667

A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system