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First, the study was conducted on a homogeneous population of working dogs with a relatively small number, which may limit the direct generalizability of the results to other canine populations, such as sedentary, geriatric, or juvenile dogs, or those of different breeds

Elderly patients should be reassured that most side effects are minor and that the benefits of correcting B12 deficiencypreventing irreversible neurological damage and anaemiafar outweigh these temporary inconveniences

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For instance, NRF2 levels in pulmonary epithelial and colorectal cancer cells and the rat retina remain unchanged or are reduced during hypoxia 4345 , suggesting that other transcription factors activated by hypoxia, such as nuclear factor kappa B (NF-B) and forkhead box O3 (FoxO), primarily lead to increased antioxidant protein expression levels 10

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