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22H04995, 20K17030 and 23K05742), AMED-CREST (grant no

However, these are indicated only for acute exposure, and acetazolamide presents adverse effects such as paresthesia, dysgeusia, hyperglycemia, and rebound symptoms, limiting its long-term use ( Consequently, studies have evaluated antioxidant compounds such as vitamins C and E, -lipoic acid, and more recently standardized Ginkgo biloba extract, which has been attributed to potential antioxidant effects

Pregnant individuals and those with complex health conditions should seek medical guidance before treatment

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In phase 3 trial (VANGUARD), 65 eligible patients were randomized into two groups: 39 received the drug as a 400 mg subcutaneous loading dose followed by five additional monthly 200 mg subcutaneous injections, whereas 25 patients received volume-matched placebo