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doi: 10.2337/diabetes.54.suppl_2.S97 22 YangSZhaoMJiaS

These include ~50 gene loci, with mutations in three Mendelian genes myocilin (MYOC), optineurin (OPTN) and TANK binding kinase (TBK1) accounting for ~5% of POAG cases with little influence from other genes or environmental factors (12, 20)